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We chose P90 as the time of investigation, because this is a symptomatic stage with profound CSMN loss, and it coincides to the disease stage, when patients show symptoms and TDP-43 pathology begins to occur

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This repair pathway acts in an error-prone manner, probably promoting chromosomal aberrations [109]

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Toxicol Appl Pharm 284:152162 Habibalahi A, Campbell JM, Bertoldo MJ, Mahbub SB, Goss DM, Ledger WL, Gilchrist RB, Wu LE, Goldys EM (2022) Unique deep radiomic signature shows NMN treatment reverses morphology of oocytes from aged mice

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